In Vivo Sr Scientist, Oncology Research at AstraZeneca

Posted in Other 5 days ago.

Location: Waltham, Massachusetts

Job Description:

In Vivo Sr Scientist, Oncology Research

Are you ready to make a difference in the world of oncology research & development? At AstraZeneca, we follow the science and turn ideas into life-changing medicines. If you have a passion for in vivo & in vitro experiments, we might be the perfect fit for you! Join us and work on the next generation new drug modalities. Embrace the opportunity to experience more than traditional molecules, combining science and the molecular machinery of cells. Stay at the forefront with our advancements in biotechnology.

As a Senior Scientist, you will be a key member of our Oncology R&D team based in Waltham, MA USA. Your role will involve delivering all aspects of in vivo pharmacology support, establishing assay systems, and delivering datasets that will have a direct impact on the drug discovery process and pipeline. You will develop, design, conduct and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will also support cross-functional teams and work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals.


AstraZeneca's Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with cutting edge technology. Our work areas were built to facilitate teamwork, interaction and cross-functional science. We believe employees benefit from being challenged and inspired at work.

The Boston R&D site located in Waltham, MA is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:

• Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails

• Flexible, agile lab design with co-located write-up space

• Vibrant site community with activities, clubs, sports & games

• Onsite business & meeting center, office, AV & catering support

• Onsite outdoor activities (e.g. frisbee golf, garden club, volleyball, etc.)

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It's home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients.

It is a great place to work in the heart of one of the world's most vibrant research cities.

Essential Skills/Experience:

• B.S, in Biology, Pharmacology or other related scientific discipline with 5+ years' biotechnology or pharmaceutical industry experience required.

• Required 3+ years' experience working on in vivo studies with antibody-drug conjugates (ADCs).

• Experience designing and performing drug combination studies with ADCs.

• Experience developing and using mouse models resistant to cancer therapies.

• Experience using syngeneic mouse models to evaluate immune-oncology therapies.

• Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic, disseminated, and autochthonous mouse models.

• Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD, and efficacy studies.

• Proficient at conventional routes of dosing administration including but not limited to intravenous, intraperitoneal, and oral gavage.

• Experience with a range of in vitro skills, e.g., cell culture, molecular biology, immunoblotting, flow cytometry, and ELISA.

• Works independently, assesses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

• Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.

• Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.

Desirable Skills/Experience:

• Experience with orthotopic xenograft and humanized models of cancer.

• Experience designing, conducting, and analyzing multi-spectral flow cytometry immune-phenotyping studies.

• Knowledge of the industrial drug discovery process.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are a science-based, leading and decisive Oncology enterprise united in our vision. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Are you ready to make a difference? Apply now and join us in our mission to eliminate cancer as a cause of death!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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