Associate Scientist II, Downstream Process Development at AstraZeneca

Posted in Other 14 days ago.

Location: New Haven, Connecticut





Job Description:

This is what you will do:


The Associate Scientist II is responsible for performing assigned experimental tasks to support the development and optimization of manufacturing processes for Alexion's biotherapeutic candidates. The Associate Scientist II will work routinely in collaboration with other members of Biologics Process Development, Technology Transfer and Analytical Sciences, including all other groups in Product Development and Clinical Supply.



You will be responsible for:




  • Conducts experimental studies to develop, optimize, and characterize manufacturing processes for biotherapeutic candidates


  • Executes experimental studies to support scale up of manufacturing processes or troubleshooting of issues at manufacturing scale as required for therapeutic proteins


  • Documents study results in notebooks, forms, and technical reports


  • Assists in laboratory management including ordering and maintenance





You will need to have:




  • BS (with 2+ years of experience) or MS degree in Biochemistry, Chemistry, Chemical Engineering or related discipline from an accredited university


  • Cross-functional problem solving skills.


  • Ability to effectively communicate scientific data in the form of presentations, experimental notebooking and authoring of technical documents.


  • Demonstrated capacity to develop deeper understandings of technical topics via research and integrate knowledge into work processes.


  • Capable of independently planing, executing and training peers on routine laboratory activities.


  • The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.





We would prefer for you to have:




  • Experience in any area of biologics process development (cell culutre and/or purification) is preferred


  • Experience performing chromatographic protein purification is preferred






  • Experience with Unicorn programming and operation of AKTA and other chromatography skids is preferred


  • Experience in nano filtration and ultrafiltration/dialfiltration is preferred


  • Proficiency with various MS Office programs, including Word, Excel, Outlook, and PowerPoint is required


  • Experience with Statistical Design of Experiments Software (e.g. JMP) is preferred




AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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