Job Title:

Post-Doctoral Scholar

DU11360

7H025:CANCER CENTER-CORE SUPPORT

Lexington, KY

$56,484 - $63,852 (dependent upon years of svc)

Temporary

Full-Time

PhD or equivalent in Microbiology or related field

Molecular Biology RESEARCH: Cell culture, animal work, western blot, qPCR, IHC, ELISA

None

Sitting at computer work station for long periods of time, Standing for long periods of time, Repetitive motion, Hazardous Chemicals or fumes, Burns/Cuts/Punctures

Monday - Friday 8a-5p, occasional overtime, some weekends required

The Markey Cancer Center is seeking a Post-Doctoral Scholar. We have established the importance of neurotensin (NT), a gut hormone peptide, in obese development and its associated metabolic disorders. Obesity is associated with an increase in colorectal cancer (CRC) incidence. We also found that NT regulates intestinal epithelial cells as well as intestinal stem cells (ISC) in a manner dependent on the availability of nutrients. Under nutrient-rich conditions, NT promotes crypt cell proliferation. Under conditions of nutrient depletion, NT enhances ISC function. Obesity may rise intestinal carcinogenesis by increasing Intestinal ISC/progenitor's population, stemness, and niche. We will investigate whether NT regulates CRC carcinogenesis via ISC or their niche. In addition, we are also interested in studying whether NT regulates CRC stem cells (CSCs). The new postdoc. will perform the in vitro experiments including cell culture, western blot, qPCR, IHC or ELISA. He/or she will perform intestinal crypt isolation and 3D organoid culture, tumor spheroid culture from patients. He/or she will also work with mice, such as sacrificing mice and collecting tissues.



This position will have the potential for a fully on-site work arrangement.



IMPORTANT: Resumes and CVs
cannot be substituted for a completed application. Incomplete applications could disqualify you from being considered for this position. If the information on your resume is not entered on the application, this will prevent us from being able to assess your education and experience when trying to determine a salary offer. To be considered you must fully complete the online application being sure to only put one (1) job title for each entry (multiple job titles for one employer must have separate entries), the # of hours worked per week and your ending salary. You will also be required to upload a Cover Letter, CV, PhD transcript and as specific request 1, a copy of your PhD diploma. Optionally, you can upload a writing sample.

To view our exceptional benefits, please visit
https://www.uky.edu/hr/benefits.

Microsoft Word, Excel, PowerPoint, Adobe photoshop, Endnote

No

Work experience in Molecular biology.

06/30/2024

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