At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new insights to life.
AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.
We are seeking a highly motivated and independent Senior Scientist with experience in radiopharmaceutical development to join our radioconjugate (RC) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. Requisites for this role include a proven track record of scientific excellence and several years of project leadership experience. As a Senior Scientist in our group, you will be the tumor biology lead for emerging RC portfolio projects, working both with our internal project teams and with external partners to develop novel targeted alpha therapies. As a core project lead, you will use your theoretical and practical expertise to deliver pre-clinical datasets, synthesize cross-functional findings, establish program priorities, and advance the project through all stages of pre-clinical development. You will represent the project team in front of governance committees and will present program updates at other internal forums. In addition to your individual project leadership responsibilities, you will also provide intellectual contributions and cross-functional support to RC teams across the portfolio.
Main Duties and Responsibilities
You will be expected to serve as the tumor biology lead for one or more radioconjugate programs, working collaboratively with internal cross-functional teams and external partners to ensure the timely generation and dissemination of critical program data to enable project milestone decisions.
As a highly organized, self-motivated individual with a strong background in cancer research and radiobiology, you will stay up to date with relevant technical, intellectual, and scientific expertise in tumor biology and cancer modelling, particularly as it relates to targeted radioconjugates, and have a genuine passion for this field of research.
Essential Requirements
PhD Degree with 0-3+ years of experience, Master's Degree with 5+ years of experience, or a Bachelor's Degree with 7+ years and project leadership experience in a relevant field related to tumor and radiation biology.
Expertise in targeted radiopharmaceutical therapies, with broad knowledge of the field, is required for consideration of the candidate.
Demonstrated ability to lead cross functional project teams.
Solid understanding of radiation biology, cell biology, and/or biochemistry in the context of cancer, with a robust desire for continued learning.
Experience with routine cell culture, particularly culture of tumor cells
Expertise in molecular- and cell-based methodologies, such as cloning/gene editing, cytotoxicity assays, binding and internalization assays, flow cytometry, ELISA, and Western blotting
Works independently with minimal supervision to conduct experiments, analyze data, and prepare results for internal and external presentations and regulatory filings
Excellent communication, presentation, and interpersonal skills evidenced by a history of successful project delivery in team-oriented, collaborative environments.
A proven track record of efficiency, as demonstrated by scientific publications in high quality peer-reviewed journals.
Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations.
Desirable Requirements
Prior experience in the biopharmaceutical industry and familiarity managing data delivery through contract research organizations preferable but not required.
Demonstrated ability to coordinate project activities and provide scientific mentorship to junior scientists is highly preferred.
Direct, hands-on experience in residualization & saturation binding assays, PET-CT imaging, biodistribution studies, non-clinical dosimetry, and other pre-clinical radioimmunoconjugate methods is highly desirable.
Experience with targeted alpha emitter therapeutics would be considered favorably.
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.
When we put unexpected teams in the same room, we unleash ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world."
So, what's next!
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
