SUMMARY/JOB PURPOSE:

The Scientist II Lead Discovery is responsible for assay development, optimization and execution of High-throughput Screening (HTS) assays and weekly screening assays to support the lead validation and lead optimization of our small molecule oncology pipeline.

ESSENTIAL DUTIES AND RESPONSIBILITIES:
• Execute HTS and routine (1-2 times per week) screening assays using automated workstations to enable identification and optimization of small molecule hits.
• Assist in establishing the HTS lab by testing the laboratory automation equipment (automated liquid handlers, dispensers, readers, etc.) to support new assay development and optimization
• Develop and optimize assays with minimal supervision to support lead validation projects: evaluate preliminary assay hits in primary assay, and develop secondary assays for characterization of compound properties, archive experimental data in ActivityBase and Genedata, prepares reports documenting the results of HTS and weekly screening campaigns
• Assist in developing, optimizing and performing the follow-up secondary assays to support lead optimization projects: support SAR evaluation, work with project teams to advance the project; provide written protocols, reports and any filing documents
• Design, troubleshoot, perform, and analyze research experiments in microplate format under minimal supervision
• May develop new methodologies and laboratory protocols in conducting general research duties within assigned area of responsibility
• Maintain, program, and operate scientific apparatus to perform research experiments
• Prepare and organize data for presentation and present data and reports on project status at individual, group, and departmental research meetings under general supervision
• Use professional concepts and company policies and procedures to solve a wide range of difficult problems in imaginative and practical ways
• Maintain familiarity with current scientific literature relevant to the research experiments or program
• Maintain laboratory notebook in a complete, consistent, and concise manner in accordance with company intellectual property policies and practices
• Adherence to good health and safety practices and compliance with applicable EH&S safety rules, and participating in mandatory safety training programs

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:
Education:
• BS in related discipline and four to six years of related experience; or,
• MS degree in related discipline and two to four years of related experience; or,
• Equivalent combination of education and experience.

Experience:
• Experience in an HTS laboratory operating automation equipment (e.g. liquid handlers, dispensers), is essential. Extensive experience in assay development for HTS applications, conducting screening campaigns, lead validation, lead optimization is preferred.
• Experience in a variety of kinase, enzymatic and cell-based assays in oncology therapeutics is required.
• Excellent data analysis skills and experience with a variety of scientific software applications (e.g. GraphPad Prism, Activity Base, Genedata) is preferred

Knowledge/Skills:
• Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required
• General knowledge of developing and executing biochemical or cellular assays is required.
• Working knowledge of automated dispensers/ liquid handlers is required.
• General understanding of how the individual experiments fit within a larger research program to meet organizational goals is required.
• General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines is required
• Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in both a team environment and independently are required.

WORKING CONDITIONS:
• Environment: primarily working in laboratories or in office
• Exposures encountered, such as hazardous materials, commonly found in a pharmaceutical laboratory setting

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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

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