Sr. Associate Scientist

Overview

Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit www.alnylam.com for more information.

We are currently seeking a passionate and experienced Senior Associate Scientist with a strong background in high-throughput in vitro screening to join our dynamic, fast-paced and interdisciplinary lead development team. Our mission is to advance novel RNAi therapeutic programs from target discovery through lead candidate selection. The successful candidate will be technically skilled in biochemistry or cell biology, and bring a rigorous, analytical approach to research.

Summary of Key Responsibilities

• The candidate will perform high-throughput screening of siRNAs using qPCR and a variety of cell-based assays.
• Design and execute in vitro screens and assays to characterize novel siRNA modifications that impact activity or uptake.
• Perform biochemical assays such as ELISA and activity assays to characterize siRNA targets and biomarkers.
• Develop and conduct assays that support in vivo studies (e.g. qPCR, ELISA) for the quantitative analysis of biomarkers or siRNA activity
• Communicate data with key stakeholders throughout the organization.
• Prepare clearly articulated experimental reports and data presentations for a variety of audiences within and outside Research
• Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results.
• The ideal candidate will be motivated and scientifically driven to support high-throughput screening efforts.

Qualifications

• A BS in a biological science with at least 3 years of hands-on laboratory experience in cell or molecular biology are required
• Experience in tissue culture and purification/quantification of nucleic acids/protein, including qPCR and ELISA
• Experience with biomarker assay development and assay optimization
• Experienced with laboratory automation including liquid handling systems such as Perkin Elmer JANUS or other systems.
• The candidate must thrive in a team environment and possess excellent communication skills (both written and oral). The role requires strong interpersonal skills, the capacity to multi-task, and the ability to function across teams. We particularly seek someone who is detail oriented and who will flourish in a goal-driven team environment under tight deadlines.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.