At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview:

The Bioproduct Research and Development (BR&D) organization strives to deliver creative medicines to patients through the development and commercialization of insulins, oligonucleotides, monoclonal antibodies, novel therapeutic proteins, and peptides. This organization is a multidisciplinary group that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, IN and Cambridge MA, scientists have full access to our scientific excellence and engineering capabilities.

Do you wish for a role working with top scientists using groundbreaking, state of the art technology? Are you looking to grow your career as a Formulations and Drug Delivery Scientist for therapies like RNA and gene delivery? If your answer is yes, then this could be the right role for you!

As a Postdoctoral Scientist -Formulation Development, the scientist will be exposed to full breadth of opportunities to develop and enable novel formulations and delivery options for oligonucleotides and/or gene delivery including Adeno-Associated Viral Vector mediated gene delivery. Therefore, the candidate must demonstrate a history of strong technical depth, scientific leadership and a willingness to promote a collaborative, team-based approach to problem solving.

Responsibilities:
The scientist is responsible for designing and conducting research to understand the interactions between proteins (antibodies and other therapeutic proteins), silicone oil, surfactants, other excipients and container/closure systems. The scientist is also responsible for working collaboratively with a wide array of scientists and engineers from many disciplines, leading/supporting relevant research initiatives, bringing new capabilities / technologies and providing internal/external influence.

The Responsibilities For This Role Will Include

• Develop nanoparticle formulations for nucleic acid therapeutics and assess what formulation parameters are needed to optimize lead formulations


• Formulate RNAs for in vitro and in vivo animal studies


• Work with the analytical team to transfer and test analytical methods to characterize formulations


• Work closely across functions to understand portfolio needs in an interdisciplinary fast paced environment


• Deliver results under tight deadlines


• Work with vendors and CROs


• Maintain thorough electronic lab notebooks and documentation records


• Adhere to all laboratory safety requirements and procedures, assist in managing lab activities including lab equipment maintenance and the ordering and receiving/shipping of lab supplies


• Create and write analytical reports and SOPs to support development


• Design and execute experiments to explore the impact of excipients on formulation stability and to understand physical and chemical stability of oligonucleotides


• Keep abreast of relevant new technologies / capabilities


• Authoring of technical reports and regulatory documents


• Present and publish research results internally and externally


• Mentor less experienced scientists and engineers to deliver the portfolio and innovation projects.

Basic Qualifications

• Ph.D. in chemical engineering, Pharmaceutical Sciences, Pharmaceutical chemistry, Biomedical engineering, biology, chemistry or a related field

Additional Skills/Preferences

• 0-5 years of prior experience in oligonucleotides and/or Gene Delivery development programs.


• Familiarity with development of formulation of adeno-associated viral vector products is highly preferred.


• Apply engineering fundamentals towards designing and optimizing drug delivery platforms which may include RNA and LNPs


• Understanding gene and cell therapies and serve as a member of integrated team responsible for the discovery and development them therapies


• Expertise in formulation, process development and optimization 


• Ability to work in the lab independently


• Strong communication skills and ability to work effectively in a highly collaborative research environment beyond BRD and Lilly, including external academic researchers and industry collaborations.

Additional Information:

• This position is not permanent. It is for a fixed term with a maximum time of 4 years

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.