The Scientist/Sr. Scientist, mRNA leads development of new technologies and optimization of existing processes around the mRNA platform. This position focuses specifically on mRNA projects and acts as the mRNA operational lead for production. In addition, the Scientist/Sr. Scientist mRNA leads the assistant scientists and serves as the technical lead for RNA manufacturing. The candidate is expected to be motivated and capable of efficient prioritization, planning and scheduling multiple projects in order to effectively meet pre-determined deadlines. The Scientist/Sr. Scientist, mRNA is responsible for completing multiple assigned tasks and projects with minimal direction.
Responsibilities
Lead manufacturing of Research Grade and GMP RNA
Be the technical/scientific lead for all RNA manufacturing
Work on the research and development of new mRNA services and technologies
Carry out experimentation in support of the developed R&D and process development plans for mRNA
Record data and create project summary reports and presenting findings and recommendations to the team.
Ensure that the all production and documentation associated with mRNA manufacture are completed by the team, and any assigned development assistance with other departments
Maintain raw material inventory needed for mRNA manufacture
Plan inventory requisitions and capex requirements
Lead drafting of Standard Operating Procedures (SOPs) and production records or master batch records as required
Work with the R&D team to research and assess process/technology improvements
Create custom development and production screening reports
Train other Assistant Scientists on mRNA manufacturing processes
Assist Metrology as needed to perform equipment calibration and preventative maintenance
Perform various QC assays in accordance with standard operating procedure for interim testing of manufactured product
Perform final adjustment and formulation, dispensing, and labelling of manufactured product
Communicate the status of operations, process issues, and safety and maintenance issues to appropriate area management
Work with technical operations to ensure smooth transition for research grade projects into GMP. Responsibilities include
Lead drafting of client specific GMP batch records
Assist ordering of materials for GMP manufacturing
Lead training and GMP manufacture
Perform appropriate aseptic technique and gowning as required for a GMP environment
Complete Quality Metrics Tracking
Required Skills
Biochemical engineering principles, including scale-up and process optimization
In vitro transcription and RNA purification
Bacterial and Mammalian culture
Proven track record of creative scientific accomplishment as evidenced by publication and/or patent record
Must be able to develop solutions for simple and complex problems, which require a high degree of ingenuity, creativity and innovation
Ability to clearly organize and document data throughout projects, as well as accurately write and present inclusive final reports
The ability to author Standard Operating Procedures (SOP’s) and train employees on implementing developed processes
Ability to work on cross functional teams and apply influencing skills in a matrix environment
Have good manual dexterity
Demonstrate high ethical standards, trustworthiness with strong communication and leadership skills
Ability to follow written procedures and written or verbal directions
Must-Haves
Ph.D. in biochemistry or related scientific field, preferred
Minimal of M.S. degree with 3 years of relevant work experience or B.S. with 5 years of relevant work experience required
Minimum 3 years of experience working in a molecular biology, biochemistry or microbiology laboratory environment
Experience in RNA manufacture, process development and optimization, experimental design, data analysis and data and concept presentation
Join Us Today!
Join a team committed to making lives better. Aldevron provides high-quality plasmid DNA, proteins, enzymes, antibodies, and other biologics to help our partners achieve significant breakthroughs for a variety of life science applications.
If you would like to thank someone for referring you to this role, please apply at www.aldevron.com/careers, and include their first and last name as a referral source!
Aldevron is committed to equal opportunity for all employees and applicants. We are committed to creating a diverse workforce and consider all qualified applicants without regard to race, religion, color, sex, national origin, age, sexual orientation, gender identify, or protected veteran status among other factors.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)
