Posted in Research 30+ days ago.
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Type: Full Time
Location: Cambridge, Massachusetts
The successful candidate will execute pre-clinical research in multiple rodent models to support therapies including gene therapy, ASO therapy, small molecules etc. A major component of this work will be the assessment of drug candidates (multiple modalities), using a wide variety of morphological and functional endpoints. This requires working closely with members of the Neuromuscular research team, as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for neurodegeneration research within Biogen.
A profound and up-to-date knowledge of concepts of neurodegenerative mechanisms and one or more disease areas (SMA, ALS, muscle degeneration etc.,) required.Strong background in genetic models of neurodegenerative diseases and experience with conducting either pharmacological or genetic tests in those models is required. Previous experience handling rodent model is required and should include some of the following: dosing, dissection, and/or surgery, behavioral endpoints assessment and analysis. A keen understanding of experimental design, underlying scientific principles, and the ability to rigorously analyze and interpret results. Sustained performance in small laboratory groups and/or project teams and ability to work successfully in a highly collaborative environment is necessary.Demonstrated ability to independently and successfully conduct research projects and publish in peer-reviewed journals. Experience in standard molecular biological techniques, biochemical techniques, cell biology is strongly preferred. Experience with viral vectors, gene therapy would be a positive addition. Excellent communication and organizational skills are critical.
Education: This position requires a Ph.D. in Neuroscience or related fields with 3+ years of postdoc or industry experience.
Neuromuscular and Movement Disorders Research at Biogen seeks a highly motivated and experienced Research Scientist to join the neurodegeneration initiatives at Biogen. Our department is responsible for research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention.