POSTDOCTORAL ASSOCIATE - Immunology at Duke University

Posted in Other 12 days ago.

Location: Durham, North Carolina

Job Description:

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Job Description:

A postdoc position in innate immunology is to investigate macrophage heterogeneity in the lung. We are interested in pulmonary infections and the lung-brain axis. We will use various omics approaches and those interested in single-cell transcriptomics techniques are also encouraged to apply. This project will emphasize complex mouse models, molecular and biochemical approaches, and immunological techniques. For more information on the Shinohara lab, please visit:

Here are recent publications from our laboratory:

  • Aggarwal, N., Deerhake, M. E., DiPalma, D., Shahi, S. K., Gaggioli, M. R., Mangalam, A. K. & Shinohara, M. L. (2021). Secreted osteopontin from CD4(+) T cells limits acute graft-versus-host disease. Cell Rep. 37: 110170.

  • Barclay, W. E., Aggarwal, N., Deerhake, M. E., Inoue, M., Nonaka, T., Nozaki, K., Luzum, N. A., Miao, E. A. & Shinohara, M. L. (2022). The AIM2 inflammasome is activated in astrocytes during the late phase of EAE. JCI Insight. 7.

  • Deerhake, M. E., Danzaki, K., Inoue, M., Cardakli, E. D., Nonaka, T., Aggarwal, N., Barclay, W. E., Ji, R. R. & Shinohara, M. L. (2021). Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 54: 484-498 e488.

  • Xu-Vanpala, S., Deerhake, M. E., Wheaton, J. D., Parker, M. E., Juvvadi, P. R., MacIver, N., Ciofani, M. & Shinohara, M. L. (2020). Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Sci Immunol. 5.

  • Kanayama, M., Xu, S., Danzaki, K., Gibson, J. R., Inoue, M., Gregory, S. G. & Shinohara, M. L. (2017). Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nat Immunol. 18: 973-984.


Self-motivated individuals who have a PhD and/or MD. The ideal candidates should have a strong background in immunology and mouse disease models. Additional expertise in molecular biology, experimental neuroscience, or genomics is greatly advantageous. Experience in EAE is desirable.

Candidates will also develop skills in mouse models of autoimmunity and neurological disorders, immune function assays, flow cytometry, microscopy, biochemistry and molecular biology techniques. The candidate will also gain considerable experience writing manuscripts, reviews and grants along with oral presentations. Additional duties will include mouse colony management, training of undergraduate and graduate students, participation in department activities, presentations at lab, local and national meetings and any other assignments that the PI may request. Collaboration and working on multiple projects are highly encouraged.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

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