We are seeking a Sr. Research Specialist who will be involved in the design and analysis of experiments using primary human samples as well as utilization of in vitro and in vivo models. The position will be responsible for successful implementation of next-generation sequencing, single-cell RNA sequencing and single cell multiomics to characterize the impact of somatic mutations on bone marrow and peripheral blood obtained from patients with clonal hematopoiesis. You will be also involved in in vitro and in vivo modeling to further define the impact of somatic mutations on hematopoiesis. This position will be presenting the results at weekly lab meetings and present the data at national and international meetings. The position will also be expected to publish data in peer-reviewed journals.
Specific Duties & Responsibilities
Performs and supervises laboratory experiments, particularly next-generation sequencing techniques, single-cell processing for various multiomics techniques.
Performs and supervises in vitro experiments using primary human bone marrow cells and cell lines, knockout and knockdown experiments using lentiviral delivery.
Works closely with institutional collaborators to provide technical and logistic support for clinical sample (blood, bone marrow, plasma) processing, analysis, data generation and maintenance of de-identified clinical information databases.
Performs flow cytometry on primary cells from patients and mice.
Reviews techniques and research protocols to ensure reproducibility and issues recommendations.
Works with laboratory staff to evaluate their technical knowledge and skills and assists in the training of other laboratory personnel.
Acts as a lead technical authority overseeing laboratory staff and is responsible for the overall daily operation of the laboratory including workload and personnel scheduling, quality control, inventory, and equipment maintenance.
Acts as the direct point of contact for industrial supplier sales personnel and technical support for both lab equipment and shared equipment which the lab uses extensively.
Supports research projects of students, fellows and other lab members as and when required.
Bachelor's Degree in Biology, Chemistry or related field.
Four year's experience in a comparable laboratory performing relevant techniques.
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.
Classified Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: $46,560-$64,100-$81,650 Annually (Commensurate with experience) Employee group: Full Time Schedule: M-F, 8:30-5:00 Exempt Status: Exempt Location: School of Medicine Campus Department name: SOM Onc Hematologic Malignancies Personnel area: School of Medicine
The referenced salary range is based on Johns Hopkins University's good faith belief at the time of posting. Actual compensation may vary based on factors such as geographic location, work experience, market conditions, education/training and skill level. Johns Hopkins offers a total rewards package that supports our employees' health, life, career and retirement. More information can be found here: https://hr.jhu.edu/benefits-worklife/
Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines:
JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
**Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.
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