Executive Director, Immuno-Oncology Research at ModernaTX, Inc.

Posted in Other 14 days ago.

Location: Cambridge, Massachusetts





Job Description:

The Role:



This is an exceptional opportunity for a talented, motivated and proven leader to advance our current preclinical portfolio and shape how we use Moderna's technology for immune-mediated cancer treatments of the near future. We have advanced 5 Development Candidates into Clinical Development and the new Executive Director will help bring the next wave(s) of impactful mRNA-based experimental medicines to cancer patients. She/he/they will focus on discovery and preclinical development of new cancer therapies with Oncology Research team members as well as representatives from multiple functions across the company. Applicants should have experience driving discovery efforts from lead identification/optimization through to IND-filing, yielding promising clinical candidates. The successful candidate must be an outstanding and rigorous scientist, an extremely effective leader, a great team player, exemplary communicator, and thrive in a fast-paced/results-oriented environment managing several projects.



Here's What You'll Do:



  • Help form overall strategy primarily with Oncology Leadership and our Strategy team, including identifying patient populations of focus with clear articulation of scientific rationale while balancing competitive landscape and medical need.


  • Oversee our discovery and early preclinical development efforts to advance new immune-oncology approaches from discovery through IND filings.


  • Identify specific signaling axes to modulate and generate concrete concepts of how our technology should be deployed for gain and loss of function approaches utilizing encoded endogenous, novel discovered and/or engineered proteins.


  • Provide guidance to Program Leaders and serve as Program Leader where necessary in cross-functional teams that may include representatives from Toxicology, DMPK, Pharmacometrics, Quantitative Bioanalytics, Translational Research, CMC, Regulatory, Clinical, etc. (depending on degree of development).


  • Help define program timelines as well as interdependencies, risks, avenues to mitigate risks.


  • Author, review and present; e.g., for internal and external presentations (from Program Team Meetings to International Conferences to EC/Board Meetings), journal articles, study reports, and IND sections.


  • Identify, connect with and help manage world-class external collaborators, partners, CROs, vendors.


  • Provide expert immune-oncology, general scientific and technical guidance to team members.


  • Supervise and mentor several scientists and help direct reports effectively manage their reports.





Here's What You'll Bring to the Table:



  • Ph.D. in Cancer Biology, Immunology, Immuno-oncology (IO), Pharmacology or related field relevant to the role with 15+ years of overall experience and >8 years drug discovery/preclinical development experience in industry.


  • Proven record in leading IO drug discovery efforts including vast knowledge of the field in general and relevant in vitro/ex vivo, in silico and in vivo animal model systems.


  • Experience bringing new programs to the clinic, in some cases as Program Leader, including establishment of Proof of Concept in appropriate ex vivo/in vivo models, and shepherding cross functional efforts through IND-filing.


  • At least 8 years leadership and management experience, including oversight of financial, IP and legal aspects.


  • Ability to effectively lead and collaborate in a dynamic, cross-functional matrixed environment.


  • Experience working with and overseeing partnerships with academic, industrial, governmental and other non-governmental organizations.


  • Outstanding communication skills (verbal and written).


  • Ability to manage multiple projects in a fast-paced environment with aggressive timelines.


  • Respectful and inclusive attitude for your colleagues/team members, in addition to your exemplary collaborative nature, boldness, curiosity and relentlessness.





Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:



  • Highly competitive and inclusive medical, dental and vision coverage options

  • Flexible Spending Accounts for medical expenses and dependent care expenses

  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities

  • Family care benefits, including subsidized back-up care options and on-demand tutoring

  • Free premium access to fitness, nutrition, and mindfulness classes

  • Exclusive preferred pricing on Peloton fitness equipment

  • Adoption and family-planning benefits

  • Dedicated care coordination support for our LGBTQ+ community

  • Generous paid time off, including:
    • Vacation, sick time and holidays
    • Volunteer time to participate within your community
    • Discretionary winter shut down
    • Paid sabbatical after 5 years; every 3 years thereafter

  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents

  • 401k match and Financial Planning tools

  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options

  • Complimentary concierge service including home services research, travel booking, and entertainment requests

  • Free parking or subsidized commuter passes

  • Location-specific perks and extras!



Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.



About Moderna



In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.


Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.


Moderna is a smoke-free, alcohol-free and drug-free work environment.


Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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