We are seeking a highly self-motivated and organized individual to work on fast-paced interdisciplinary collaborative projects in the Traverso Lab at Brigham and Women's Hospital. The projects focus on the development of drug delivery systems and bioadhesive administration devices for controlled/sustained drug delivery applications in the field of ocular drug delivery and the ex vivo assessment of permeation enhancing and bioadhesive agents on mucosal tissues, more specifically on esophageal tissue for increasing esophageal drug permeability and retention, respectively. Primary responsibilities include formulation development and physicochemical characterizations (scanning electron microscopy, differential scanning calorimetry, X-ray diffraction analysis, mechanical characterizations etc.), in vitro drug release assessment (eg., HPLC), ex vivo permeability assays across animal tissues (cornea and esophagus), ex vivo assessment of bioadhesion on animal tissues (cornea and esophagus) and preclinical evaluation of the delivery systems in relevant small (rabbits) and large animal models (retention, pharmacokinetics, pharmacodynamics and toxicity). General responsibilities include operating lab equipment, conducting experiments, collecting data, recording and documenting experimental procedures and results, consulting scientific literature as needed, analyzing and summarizing results, and working with a multidisciplinary team of researchers.
B.S./B.A. major in chemical engineering, pharmaceutical, biological/biomedical engineering, chemistry, biology science or a field directly related to the work.
Commitment to producing accurate and high-quality data.
Experience of conducting tests following instructions and operating and maintaining technical instruments/equipment.
At least one wet lab experience working in a laboratory environment prior to applying for this position.
Strong organizational, time management and documentation skills.
Excellent analytical skills and strong communication and writing skills.
Proficient with analyzing, summarizing, and reporting results.
Willingness to learn new scientific tools and techniques quickly.
Applicant will be trained to perform techniques required in experiments, including techniques related to animal work. After sufficient training, the intern is expected to work independently with minimal supervision.
Awareness of basic safety requirements and ability to follow safety procedures and maintain a safe work environment.
PREFERRED (whichever applies):
Relevant experience in formulation development and in vitro characterization techniques.
Relevant experience with tissue handling and animal work techniques.
The co-op term is 6 - 8 months (longer term is preferred).
BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.