SUMMARY/JOB PURPOSE:

Discovery Biotherapeutics is seeking an experienced, self-motivated Principal Scientist to provide cell biology and translational support for the advancement of immune-oncology (I-O) bispecific and immunocytokine portfolio at Exelixis. The successful candidate must have strong immunology and in vitro cell biology background as he/she will lead in vitro and ex vivo assay development and early translational activities for bispecific and immunocytokine programs.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Project lead and contribute actively to bispecific and immunocytokine pipeline development from discovery to lead selection


• Design, implement and manage in vitro mechanism of action validation assays in support of bispecific and immunocytokine programs (e.g., cytotoxicity assays, immunological assays, ELISA, FACS etc.)


• Design, implement and manage biomarker and tissue staining for translational characterization of disease-related targets enabling earlier decision for programs


• Critical scientific/technical data analysis, interpretation of experiments and report writing.


• Effectively and timely communicate scientific concepts, findings and interpretation to multi-disciplinary teams.


• Interacts and collaborates with internal departments and external collaborators to deliver quality and timely findings in support of drug candidate advancement.


• Follows company intellectual property and compliance policies and practices.


• Complies with company health and safety policies and general laboratory practices.

SUPERVISORY RESPONSIBILITIES:

• Supervises, hires, trains, provides work direction, and problem-solving assistance for Scientist(s).

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

• Bachelor's degree in Immunology, Cancer Biology or a closely related field and a minimum of eighteen years of related experience; or

• Master's degree in Immunology, Cancer Biology or a closely related field and a minimum of sixteen years of related experience; or

• Ph.D. in Immunology, Cancer Biology or a closely related field and a minimum of six years of experience and/or training in biotechnology/pharmaceutical industry post Ph.D.


• Equivalent combination of education and experience.

Experience:

• I-O experience in biologics-based drug development in biotechnology/pharmaceutical setting is essential.

• Extensive experience in setting up MOA-based cell-based validation assays a must.


• Strong CRO management experience for out-sourcing of in vitro and translational experiments a must.

Knowledge/Skills:

• Proficiency in immunology-based in vitro and translational assays.


• Strong scientific understanding of in vitro and translational characterization of biologics (bispecifics and immunocytokines a plus) from discovery to lead selection is essential.


• Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems.


• Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously.


• Excellent written, oral and interpersonal communication skills.


• A strong team player.


• Skillful in mammalian cell culture and related techniques.


• Good knowledge in Flow cytometry and histology.


• Advanced knowledge in Excel, Word, PowerPoint, PDF, Graphpad prism.


• Good tracking record and report writing.

WORKING CONDITIONS:

• Environment: primarily working in laboratories and/or in office

• Exposures encountered, such as hazardous materials, extreme cold.

• Minimum travel required (10%)

If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

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