The Scientist I, HTS is responsible for assisting in the development and completing the assay execution of both high throughput screening (HTS) campaigns in 1536-well plate format and weekly screening campaigns in 384-well plate format using the appropriate automation.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
Complete the execution of HTS and weekly screening assays including data quality control and upload into the appropriate databases
Assist in establishing the HTS lab by testing the laboratory automation equipment to support new assay development and optimization
Assist in developing and optimizing assays to support lead validation projects: evaluate preliminary assay hits in primary assay, and develop secondary assays for characterization of compound properties, archive experimental data in a data management system, prepares reports documenting the results of HTS campaigns
Assist in developing, optimizing and performing the follow-up secondary assays to support lead optimization projects: support SAR evaluation, work with project teams to advance the project; provide written protocols, reports and any filing documents
Design, troubleshoot, perform, and analyze research experiments in microplate format under moderate/close supervision
May develop new methodologies and laboratory protocols in conducting general research duties within assigned area of responsibility
Maintain, program, and operate scientific apparatus to perform research experiments
Prepare and organize data for presentation; present data and reports on project status at individual, group, and departmental research meetings under general supervision
Use professional concepts and company's policies and procedures to solve a wide range of difficult problems in imaginative and practical ways
Maintain familiarity with current scientific literature relevant to the research experiments or program
Maintain laboratory notebook in a complete, consistent, and concise manner in accordance with company intellectual property policies and practices
Adherence to good health and safety practices and compliance with applicable EH&S safety rules, and participating in mandatory safety training programs
SUPERVISORY RESPONSIBILITIES:
None
EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:
Education/Experience:
BS in related discipline and a minimum of one year of related experience; or
MS degree in related discipline and zero or more years of related experience; or
Equivalent combination of education and experience.
Experience/The Ideal for Successful Entry into Job:
Experience in an HTS laboratory operating automation equipment (e.g. liquid handlers, dispensers), is highly desirable. Extensive experience in assay development for HTS applications, conducting screening campaigns, lead validation, lead optimization is preferred.
Experience in a variety of kinase, enzymatic and cell-based assays in oncology therapeutics is a plus.
Excellent data analysis skills and experience with a variety of scientific software applications (e.g. GraphPad Prism, Activity Base, Genedata) is preferred
Knowledge/Skills:
Strong background in automation and experience with liquid handlers (Echo, Biomek i7, Tempest, etc.) is a plus.
Significant knowledge and proficiency in development of HTS assays in biochemistry, enzymology, and cell biology is preferred.
General understanding of how the individual experiments fit within a larger research program to meet organizational goals.
General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines.
Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in both a team environment and independently.
Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required.
JOB COMPLEXITY:
Works on problems of diverse scope where analysis of data requires evaluation of identifiable factors.
Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
With guidance, designs, executes, and interprets scientific experiments to drive decisions regarding compound function
WORKING CONDITIONS:
DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state, or local protected class.
If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!
DISCLAIMER The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.
