Research Scientist at University of Pittsburgh

Posted in Science 9 days ago.

Location: Pittsburgh, Pennsylvania





Job Description:

UPCI Research Lab-Shlomchik, Warren - Pennsylvania-Pittsburgh - (22000412)

The University of Pittsburgh is seeking a Research Scientist to work in the laboratory of Dr. Warren Shlomchik at the UPMC Hillman Cancer Center. The candidate will study the mechanisms whereby interferon-gamma sensitizes leukemia cells to killing by alloreactive T cells. The project employs CRISPR-editing of novel mouse leukemia lines derived from compound oncogene knockin mice, single cell RNA sequencing, ATAC-seq, in vivo studies with novel T cell receptor transgenic mice, and CRISPR-Cas9-screens to identify genes that both render leukemia cells resistant to T cell killing. Specific skills and knowledge that are essential for the position:1) Knowledge of immunology, particularly cellular immunology is highly valued2) Knowledge of malignant hematology is highly valued3) Experience with mouse handling4) Experience with CRISPR-Cas9 genome editing5) Expertise in multi-parameter flow cytometry6) Expertise in common molecular biology techniques including modern cloning, PCR, RT-PCR.

PhD in a biological science with 5 years of postdoctoral training preferred. Specific skills and knowledge that are essential for the position:1) Knowledge of immunology, particularly cellular immunology is highly valued2) Knowledge of malignant hematology is highly valued3) Experience with mouse handling4) Experience with CRISPR-Cas9 genome editing5) Expertise in multi-parameter flow cytometry6) Expertise in common molecular biology techniques including modern cloning, PCR, RT-PCR.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets

Department Details The University of Pittsburgh requires all Pitt constituents (employees and students) on all campuses to be vaccinated against COVID-19 or have an approved exemption. Visit coronavirus.pitt.edu to learn more about this requirement.
Job Classification Full-time regular
Campus Staff.Research Scientist.Scientist
Minimum Education Level Required Pittsburgh
Minimum Experience Level Required PhD or ScD
Work Schedule 3-5 years experience
Hiring Range $46,644.00 - $76,440.00
Relocation Offered No
Visa Sponsorship Provided No
Background Check No
Child Protection Clearances For position finalists, employment with the University will require successful completion of a background check
Required Documents Resume
Optional Documents Cover Letter

PI161107634


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