Informatician at Mass General Brigham(PHS)

Posted in Other 2 days ago.

Location: Cambridge, Massachusetts

Job Description:

Would you like to be a part of team advancing clinical genomics and improving medical care for patients facing life threatening diseases? MGB Personalized Medicine is a leader and innovator helping realize the promise of personalized medicine by accelerating the integration of genetic knowledge into clinical care. We are seeking a bioinformatician to focus on continuously advancing the state of the art of research and clinical genetic testing. This position offers an opportunity to become a part of a highly engaged team with multiple interactions across the center, including with members of our translational research core, clinical laboratory, Biobank, and IT team. Duties will include building robust scalable pipelines and data mining tools for sequencing applications in addition to providing informatics support for the development of clinical diagnostic tests. Applicant will also support many of the large-scale and collaborative grant-funded activities at the center.

We are specifically looking for an independent individual who can contribute to multiple projects as part of a highly-integrated team with frequent interactions. A successful candidate should have a strong scientific and quantitative background with prior exposure to genetics and/or genomics, excellent problem-solving and programmatic skills, and the ability to effectively communicate and interact with multidisciplinary staff in a fast-paced environment.


  • Assist in building different modules of software pipelines for genomic applications

  • Provide informatics support in development of clinical diagnostic and screening assays, including in support of translational research projects

  • Assist in mining/annotation of genomic and clinical data. A strong understanding of the principles of genetics is a preferred plus.

  • Assist with current clinical and research operation pipelines

  • Assist with data quality assessment and troubleshooting

  • Assist in the analysis, acquisition, and loading of new data sources

  • Work collaboratively with the group

  • Create testing, validation, and standard operation procedure documentation

  • Qualifications

    • M.Sc. in bioinformatics, computer science or related field

    • Experience in a Unix/Linux environment, including proficiency in shell scripting, and scripting in a language such as Perl or Python

    • Basic knowledge of algorithms, data structures, and scientific programming

    • Proficiency in shell scripting and in submitting jobs in a HPC environment

    • Experience with common bioinformatics databases and genome browsers

    • Understanding and usage of biostatistics and bioinformatics tools, including common NGS tools (e.g. BWA, samtools, Picard, GATK) and statistical/visualization packages (e.g. R, Bioperl, MATLAB)

    • Ability to work on multiple projects. This is a dynamic environment where priorities often change

    • Ability to work with others to set realistic goals and deliver quality work, on schedule

    • Strong interest in molecular biology and genetics, and a willingness to learn concepts and terminology from these fields as

    Additional Qualifications

    • Experience with machine learning algorithms

    • Experience with automation for analysis of large, complex data sets

    • Strong interpersonal skills and ability to work as part of a diverse team, while contributing to a high-quality and respectful work environment

    • Excellent oral and written communication skills

    EEO Statement

    Mass General Brigham is an Equal Opportunity Employer & by embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law.
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