Posted in Other 30+ days ago.
Location: Cambridge, Massachusetts
The Role:
We are looking for an innovative and motivated biologist or chemical biologist to support advancement of Moderna mRNA technology platform and pipeline. Applicants will utilize a wide range of microscopy, molecular and cell biology techniques to investigate cellular uptake and distribution of mRNA and proteins using in vitro models. Specifically, this position will contribute to development on novel live-cell imaging modalities to characterize intracellular steps involved in mRNA delivery with lipid nanoparticles. Additionally, the candidate will contribute to development of novel formulations, and establish analytical, biophysical and cell biology methodology to characterize LNP potency and interactions with biological barriers.
Here's What You'll Do:
Drive microscopy-based investigations to evaluate novel delivery vectors
Execute and troubleshoot immunofluorescence protocols, independently adapt new protocols into practice, and query the literature to incorporate additional assays as needed
Introduce new imaging technology and probe development
Analyze, interpret and present data to internal parties
Accountable for project success and results delivery
Closely collaborate with other members within the Biological Science department and broadly with departments throughout the company
Here's What You'll Bring to the Table:
Minimum Qualifications
PhD with 0-2 years of industry experience (Biomedical Engineering, Chemistry/Biochemistry, Biophysics or related science), developing and performing cellular and biochemical assays
Experience in quantitative fluorescence imaging
Demonstrated application of mammalian cell culture and associated techniques
Preferred Qualifications
Experience in quantitative image analysis - prior experience with an image quantitation package (e.g. Volocity, ImageJ, Imaris, Metamorph, Harmony) is highly desirable
Familiarity with nucleic acid therapeutic characterization
Excellent interpersonal, organizational, and collaborative skills, attentive to detail, and the ability to work independently and effectively in a highly dynamic environment
Ability to multi-task to meet aggressive timelines and development goals
Here's What We'll Bring to the Table:
About Moderna:
In 10 years since its inception, Moderna has transformed from a science research-stage company advancing programs in the promising-but-still-unproven field of messenger RNA (mRNA), to an enterprise with its first medicine having treated millions of people, a diverse clinical portfolio of vaccines and therapeutics across six modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for both clinical and commercial production at scale and at unprecedented speed. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use of one of the earliest and most-effective vaccines against the COVID-19 pandemic.
Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and auto-immune diseases. Today, 24 development programs are underway across these therapeutic areas, with 13 programs having entered the clinic. Moderna has been named a top biopharmaceutical employer by Science for the past six years. To learn more, visit www.modernatx.com.
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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