Scientist II/Sr. Scientist, mRNA Therapy at Astellas

Posted in Other 11 days ago.

Location: Cambridge, Massachusetts





Job Description:

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture.

There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

Astellas is announcing a Sr. Scientist, mRNA Therapy opportunity at their Astellas Innovation Management (AIM) site in Cambridge, MA.

Purpose:

The Incubation Research Laboratory (iLab) is part of Astellas Innovation Management, a recently established Research and Development division of Astellas located in a state-of-the-art facility in the heart of the Cambridge biomedical ecosystem.

We are looking for a creative and energetic scientist to conceptualize new projects. The candidate must be capable of defining technical objectives of new and existing programs and to plan the execution of efforts and perform experiments to meet objectives. She/he will 1) apply expertise and scientific knowledge to ongoing research and toward development of new project proposals; 2) plan and direct laboratory Research and Development activities by assessing underlying technical and conceptual risks and defining approaches and methodologies, which are innovative and creative, in order to achieve goals; 3) Initiate projects that have risks such as development of novel technologies or application of individual expertise to new areas; 4)Take a leadership role contributing across internal cross-functional groups, and through familiarity with scientific literature and participation at conferences.

The successful candidate will have a specific understanding of mRNA therapy field on both technological perspective and biological perspective with deep understanding of multiple disease relevant biologics.

Essential Job Responsibilities:


* Performs research on mRNA therapy (mRNA direct administration as therapeutic modality)
* Prepares technical reports, summaries, protocols, and quantitative analyses. Investigates, creates and develops new methods and technologies for project advancement.
* Detail-oriented, self-motivated and capable of initiating establishment of new/existing methodologies to support new and ongoing projects
* Aligns with company's objectives and project timelines to solve complex problems in creative and effective ways
* Works in collaboration with Astellas R&D, CROs, consultants and academia
* Maintains guidelines for lab supplies, instruments, lab data records, and lab safety.

Qualifications:

Required


* Education and Experience:


* Scientist II: PhD with 3+, MS with 7+, or BS with 10+ years' experience in drug discovery, biotechnology, or academic leadership.
* Scientist: PhD with 5+, MS with 8+, or BS with 12+ years' experience in drug discovery, biotechnology, or academic leadership.
* Demonstrated industry experience or academic achievement, as evidenced by high quality publications and/or contribution to drug development portfolio
* Ability to collaborate with external partners across multiple scientific disciplines
* Excellent written and oral communication skills
* Experience in standard molecular biology, biochemistry, and pharmacology

Preferred

1 or more of the qualifications below:


* Expertise in in vitro and in vivo assays on IVT mRNA
* Knowledge and expertise in mRNA delivery cargo (eg. Lipid nanoparticle)
* Previous experience in in vitro cell based assay development for drug discovery
* Previous experience in in vivo animal study for model establishment and/or compound evaluation

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