Job Description:

Description

POSITION SUMMARY:

This job is responsible for manufacturing products using instruments and biochemical processes. The incumbent will utilize techniques such as size exclusion chromatography purification/analysis, oligonucleotide deprotection/conjugation, gel filtration, centrifugation, spectrophotometry, reconstitution, and various assays.

DUTIES AND RESPONSIBILITIES:

• Purify protein solutions via FPLC or spin column gel filtration to prepare conjugation/coating solutions or remove free-tag


• Utilize HPLC to perform size exclusion chromatography analysis on customer samples in order to report percentages of monomer, aggregation, and free-tag


• Manufacture products by deprotecting oligonucleotide solutions utilizing various chemistries




• Conjugate oligonucleotide solutions to various proteins




• Conjugate antibodies with Biotin or SULFO-TAG NHS-Ester in order to produce detection/capture antibodies for use in catalog and custom kits
  
  


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  Quantify protein concentrations utilizing techniques such as spectrophotometry or BCA Assay

  
  


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  Run assays to quantify biotin/protein ratios or glycerol content in solution

  
  


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  Manufacture customer contract materials with specialized procedure and handling requirements

  
  


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  Assist the Supervisor in training of new manufacturing personnel

  
  


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  Review production records to ensure technicial accuracy and compliance with GDP

  
  


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  Maintain preventative maintanence schedules for lab equipment

  
  


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  Provide input and execute tasks to improve routine manufacturing processes that provide for better quality and quantity of products

  
  


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  Update Standard Operating Procedures or Batch Records as needed

  
  


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  Participate in technicial transfer of new processes into the Biochemical Manufacturing team by providing feedback on draft documents and shadowing new production processes during development.
  

  
  


• Participation in general laboratory maintenance including maintaining laboratory cleanliness, supplies and equipment

• Prepare, maintain and report raw material or reagent inventories.


• Participate in year-end physical inventory




• Specific duties may vary depending upon departmental requirements

EXPERIENCE AND QUALIFICATIONS:

• Bachelor's degree in Biology, Chemistry, Biotechnology, Engineering or related field; or an Associate's degree with equivalent applicable work experience.


• Two years experience in a manufacturing role utilizing biochemistry techniques

KNOWLEDGE, SKILLS AND ABILITIES:

• A demonstrated aptitude for learning and adhering to standard laboratory techniques and safety precautions


• Thorough knowledge of scientific fundamentals and analytical background


• Demonstrate a mechanical aptitude including equipment troubleshooting


• Excellent oral, written communication and interpersonal skills




• Effectively communicate issues/problems and results that impact timelines, accuracy and reliability of laboratory data




• Proficiency in MS Office Suite
  
  


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  Ability to follow laboratory safety instructions; ability to use protective equipment.

  
  


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  Ability to multi-task and work productively in a demanding manufacturing environment with changing priorities

  
  


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  Knowledge of cGMP and/or ISO certification highly preferred

  
  


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  Ability to learn additional software applications/tools, as required

  
  


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  Knowledge of JDE is highly preferred

  
  


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  Knowledge of FPLC or HPLC highly preferred

  
  


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  Knowledge of Akta systems highly preferred

  
  

PHYSICAL DEMANDS:

• This position requires the ability to communicate and exchange information, utilize equipment necessary to perform the job, and frequent lifting up to 25 lbs.


• Up to 80% of the day may be spent at a lab bench and/or in the cleanroom

WORK ENVIRONMENT:

Standard industrial laboratory environment

Qualifications

EducationBachelors of Biology (required)



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