Job Description

We are seeking an experimental research scientist to join a new team at the Broad Institute to build a Human Gene Regulation Map, and link this Map to Cellular Programs.

This position will be embedded in the Claussnitzer lab in close collaboration with the Lander and Engreitz labs and will seek to understand the fundamental wiring of the genome in mesenchymal stem cell lineages and build a reference atlas for discovering molecular and cellular programs underlying common genetic diseases.

In the Claussnitzer lab, we are passionate about discovering and understanding cellular programs underlying metabolic diseases and gene regulation via non-coding regulatory elements acting in differentiating adipocytes, and other mesenchymal stem cell lineages. DNA regulatory elements in adipocytes are enriched for thousands of risk variants and can serve as targets for therapeutics aimed at precisely tuning specific cellular functions.

We are looking for a highly creative, resourceful, integrative thinker to join this team and make fundamental discoveries in mapping enhancer-promoter connections in multiple mesenchymal cell lineages, understanding cellular programs at large scale and developing new tools to help uncover mechanisms underlying metabolic diseases. Specifically, we are looking for candidates who can lead population-scale phenotypic characterization efforts which include application of single cell technologies and CRISPR-based screening tools with multiple readouts including- single cell transcriptomics, epigenomics and high-content imaging technologies.

The Claussnitzer Laboratory is a dynamic, innovative and interdisciplinary group and is seeking to hire an exceptional scientist who will have the opportunity to work with people in the lab as well as the wider Broad community. Candidates in this position will also have access to various new emerging technologies with the potential towards making significant scientific contributions in various disease areas.

CHARACTERISTIC DUTIES

• Lead and collaborate with scientists and research associates to make fundamental discoveries about genetic variant to gene to cellular function




• Develop and apply functional genomics techniques, including epigenomics, single-cell, transcriptomics, high-content imaging technologies and CRISPR-based assays in primary adipose-derived mesenchymal stem cells




• Work with people in the Claussnitzer, Lander and Engreitz groups as well as the wider Broad community to integrate emerging technology and streamline data generation and analysis.




• Design and lead projects including developing methods, techniques and evaluation criteria for obtaining results




• Demonstrate scientific creativity and collaboration to expand technical capabilities in to new applications and identify new research opportunities




• Train and mentor other lab members




• Make significant contributions to scientific papers, quantitative data analyses and presentations




• Contribute to generation of protocols and data analyses




• Manage and work with multidisciplinary team to achieve project goals

REQUIREMENTS

• Ph.D. in Molecular Biology, Biochemistry, Genetics or related life science field




• Additional 3+ years of relevant laboratory experience in academic or industry setting strongly preferred




• Strong hands-on experience in molecular biology, genomics, and cellular biology (cell-based assays, primary and cell line culture)




• Experience with genome editing tools including, CRISPR targeting in various human cell types including human MSC cells or single-cell RNA-seq highly desirable




• Experience with quantitative data analysis. Proficiency in computational methods is a plus




• Proven track record of critical scientific thinking, multi-tasking ability, and strong analytical and problem-solving skills




• Excellent interpersonal and collaborative skills, and the ability to work both independently and as part of a team with scientists from a wide range of research expertise




• Outstanding verbal and written communication abilities




• Ability to adapt to and effectively manage changes in a fast paced and dynamic environment

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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