The Sr. Scientist, Upstream Process Development (USPD) has strong working knowledge of microbial systems, bacterial metabolism, protein expression and current bioprocessing technologies. The Sr. Scientist, USPD has a proven track record of developing processes for expression of recombinant proteins using microbial fermentation systems. Critical thinking with a continuous improvement mind-set and the ability to develop and troubleshoot expression methods is a must. The Sr. Scientist, USPD will be primarily responsible for developing processes that can be scaled from shake flasks to 1000-L scale microbial fermentations.

Responsibilities

• Independently develop processes for expression of recombinant proteins from microbial expression systems


• Optimize expression systems to provide the most recombinant protein that can still be purified by the downstream processing methods


• Devise fermentation production processes that can be scaled from sub-liter shake flask cultures to 1000-L bioreactors


• Actively collaborate with upstream manufacturing to improve process robustness and performance


• Identify and evaluate new technologies for fermentation and recombinant protein expression


• Draft and execute research plans, including timeline and budget


• Serve as a technical resource to Aldevron colleagues and clients


• Organize technical data into scientific reports and effectively communicate to internal colleagues and external clients


• Review and approve SOPs and Batch Record forms for fermentation processes


• Assist in the technical transfer of fermentation processes from process development to research grade and GMP manufacturing


• Lead the USPD team and serve as SME for all USPD-related discussions


• Mentor and train team members


• Productively work on multiple projects simultaneously


• Accurately record experimental results in real-time


• Demonstrate high ethical standards, good judgement and trustworthiness

Required Skills

• Proficient with Quality Management Systems, familiarity with ISO certified labs and GMP working environments


• Great attention to detail


• Ability to maintain accurate lab documentation


• Proficient with Microsoft Office

Must-Haves

• Degree in biology, molecular biology, biochemistry, chemistry, or a closely related field
  
  
  
  • B.S. and 10+ years of relevant work experience
  
  
  • M.S. and 6+ years of relevant work experience
  
  
  • Ph.D. and 2+ years of relevant work experience
  
  
  
  


• Extensive, hands-on experience with microbial fermentation methods:
  
  
  
  • Operating bench-top and lab-scale bioreactors
  
  
  • Developing batch and fed-batch fermentation processes
  
  
  • Execute upstream design of experiment (DOE) utilizing multi-reactor systems
  
  
  
  


• Experience with typical fermentation analytical testing, like gas or sugar analysis


• Experience with Ambr systems and Sartorius bioreactors and the software for the process controllers


• Experience with pilot-scale bioreactors and harvest systems


• Experience with microbial fermentation to express recombinant proteins


• Experience with various promoter systems and expression plasmids


• Experience with USPD equipment, ie DASGIP System, Ambr

Join Us Today!

Join a team committed to making lives better. Aldevron provides high-quality plasmid DNA, proteins, enzymes, antibodies, and other biologics to help our partners achieve significant breakthroughs for a variety of life science applications.

If you would like to thank someone for referring you to this role, please apply at www.aldevron.com/careers, and include their first and last name as a referral source!

Aldevron is committed to equal opportunity for all employees and applicants. We are committed to creating a diverse workforce and consider all qualified applicants without regard to race, religion, color, sex, national origin, age, sexual orientation, gender identify, or protected veteran status among other factors.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)

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