Scientist, Investigative Pathology at Alnylam Pharmaceuticals

Posted in General Business 5 days ago.

This job brought to you by eQuest

Type: Full-Time
Location: Cambridge, Massachusetts

Job Description:

Scientist, Investigative Pathology


Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with two approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,400 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work five years in a row (2015-2019), a Great Place to Work in the U.K. and Switzerland in 2020 and Science Magazine's #1 Top Employer in 2019. Please visit for more information.

Alnylam Pharmaceuticals has a full-time opening at the Scientist level in Investigative Pathology (iPath). The successful applicant will collate internal and external data, conceive sound hypotheses, and design and execute studies to interrogate them. Generation and analysis of high quality molecular and in vivo data is expected in order to advance our platform, safety and therapeutic discovery efforts. Facility with routine molecular assays is required, as well as the ability to learn new techniques. Performance of in vivo rodent studies with the assistance of the vivarium is an integral component of the position. Cell culture experience is a bonus.

iPath seeks to understand mechanisms underlying RNAi tissue distribution, trafficking, molecular interactions, and off-target effects. Additionally, the group utilizes animal models for discovery, and identifies novel targets for the intervention of important human diseases. Current therapeutic areas include liver, CNS and eye. A key component of this position is to help expand our therapeutic range into new cell types. The Scientist will take ownership of vital research areas and increase our mechanistic understanding therein. The successful applicant will join a vibrant team of highly motivated scientists across a broad array of disciplinary expertise areas. Experience in neuroscience is desirable, but all outstanding candidates are encouraged to apply.

Summary of Key Responsibilities

  • Conceive, design, and execute impactful molecular and in vivo studies.
  • Perform routine molecular assays including but not limited to protein and nucleic acid purification, PCR, ELISA, Western blot, etc.
  • Learn novel techniques as required to address specific questions.
  • Design, direct and analyze in vivo rodent studies.
  • Maintain notebooks and generate validated and reproducible data in a timely fashion.
  • Communicate findings in clear and concise reports and scientific presentations.
  • Collaboratively interact with other scientists to accomplish cross-disciplinary objectives.


  • PhD in biology or related field. Post-doctoral experience desirable.
  • Excellent communication skills; fluent in oral and written English.
  • Innovative thinker supported by strong critical reasoning.
  • Facility with routine molecular techniques. Cell culture experience a bonus.
  • Demonstrated experience designing and performing in vivo rodent studies.
  • Familiar with Microsoft Office and science-related software.
  • Ability to multitask and work in a fast-paced environment with minimal supervision.
  • Collegial team player with excellent interpersonal skills

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.