Posted in General Business 5 days ago.
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Location: Cambridge, Massachusetts
Scientist, Investigative Pathology
Alnylam is the world's leading RNA interference (RNAi) company.
Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with two approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.
Headquartered in Cambridge, Mass., Alnylam employs over 1,400 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work five years in a row (2015-2019), a Great Place to Work in the U.K. and Switzerland in 2020 and Science Magazine's #1 Top Employer in 2019. Please visit www.alnylam.com for more information.
Alnylam Pharmaceuticals has a full-time opening at the Scientist level in Investigative Pathology (iPath). The successful applicant will collate internal and external data, conceive sound hypotheses, and design and execute studies to interrogate them. Generation and analysis of high quality molecular and in vivo data is expected in order to advance our platform, safety and therapeutic discovery efforts. Facility with routine molecular assays is required, as well as the ability to learn new techniques. Performance of in vivo rodent studies with the assistance of the vivarium is an integral component of the position. Cell culture experience is a bonus.
iPath seeks to understand mechanisms underlying RNAi tissue distribution, trafficking, molecular interactions, and off-target effects. Additionally, the group utilizes animal models for discovery, and identifies novel targets for the intervention of important human diseases. Current therapeutic areas include liver, CNS and eye. A key component of this position is to help expand our therapeutic range into new cell types. The Scientist will take ownership of vital research areas and increase our mechanistic understanding therein. The successful applicant will join a vibrant team of highly motivated scientists across a broad array of disciplinary expertise areas. Experience in neuroscience is desirable, but all outstanding candidates are encouraged to apply.
Summary of Key Responsibilities