Job Description:

Description

One Brave Idea (OBI) is currently seeking a motivated, enthusiastic, and talented individual to conduct translational research experiments related to novel phenotyping of cardiovascular disease. The Technical Research Assistant will assist in characterizing study participants' genomes, transcriptomes, proteomes, and non-molecular phenotypes in order to facilitate discovery of 1) novel markers of coronary artery disease at its earliest stages; and 2) insight into its disease mechanisms.The primary project involves generation of data for downstream use in unsupervised machine learning projects.Because much of the work is high-throughput and team-based, the candidate will closely collaborate with a group of research assistants, post-docs, and data scientists.TheTechnical Research Assistant will report directly to the Science Operations Lead.

OBI is a unique $75 million investment focused on combating coronary heart disease, enabled by a collaboration between the American Heart Association, Verily, AstraZeneca, and Quest Diagnostics.The goal of the investment is tocombine innovative participant phenotyping, large scale genetic, genomic and proteomic characterization, and mechanistic cell biology to enable novel discoveries and drive their application to clinical practice.OBI's current activities include work in data analytics, genomics, genetics, cell biology, care redesign, and machine learning. The organization is composed of approximately 40 individuals including faculty, staff, and research and clinical fellows and associates. OBI operates with a startup mentality - as such, the Technical Research Assistant must be able to adapt to evolving goals and priorities.

Responsibilities

1. Perform a variety of laboratory experiments under general supervision. These will include molecular and cellular techniques, flow cytometry, DNA and RNA extraction, qPCR, DNA and RNA sequencing, (multiplex) qPCR, cell sorting, and proteomic analysis.


2. Collaborate with team of research assistants to meet project goals in a fast-paced and dynamic wet lab setting.


3. Help to establish new and modify existing research techniques.


4. Meticulously record procedures and results in an electronic lab notebook; follow the required safe practices and comply with institutional policies and procedures.


5. Help to maintain and calibrate laboratory equipment.


6. Help to coordinate with core facilities and collaborating labs.


7. Discuss progress of work regularly with the Science Operations Lead, Director of Operations, and Chief Data Scientist.


8. Maintain tissue cultures of cell lines and monitor cells for viability and contamination.


9. Help prepare presentations, project reports, and written articles for publication.


10. Collect data and analyze results using basic statistics.


11. May be asked to work on some nights and weekends if needed (overtime will apply).

SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:

• Ability to perform a variety of laboratory experiments related to molecular and cellular biology.


• Exceptional ability to participate in team-based, high-throughput laboratory activities.


• Adaptability to changing experimental protocols and willingness to participate in setting up new protocols.


• Strong organizational skills, detail oriented.


• Ability to maintain an accurate and complete electronic lab notebook and electronic logs of stored samples.


• Knowledge of sterile techniques including ability to use pipettes, test tubes, culture dishes and flasks in a cell culture hood.


• Excellent analytical and communication skills.


• Interest in and willingness to accept new responsibilities.


• High personal standards for quality, accuracy, and completeness of experimental work.
  

Qualifications

QUALIFICATIONS:

Required:

• BA in biology or chemistry or a closely related field

Preferred:

• Prior laboratory research experience.


• Experience with statistical analysis and/or computer programming.

EEO Statement

Brigham and Women's Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, creed, sex, sexual orientation, gender identity, national origin, ancestry, age, veteran status, disability unrelated to job requirements, genetic information, military service, or other protected status.

Primary Location

:MA-Brookline-BWH Brookline Hills BWPO Administration

Work Locations

:BWH Brookline Hills BWPO Administration111 Cypress StBrookline02447

Job

:Technician/Technologist/Scientist

Organization

:Brigham & Women's Hospital(BWH)

Schedule

:Full-timeStandard Hours:40

Shift

:Day Job

Employee Status

:RegularRecruiting Department:BWH Department Of Medicine / Cardiovascular Medicine

Job Posting

:Jan 14, 2021

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