Job Description:

Yoh is seeking a Scientist I, Analytical and Formulation Development to support our Biotech client in South San Francisco, CA. This is a direct hire opportunity. Please note this is an onsite, lab-based role.

See below for complete job responsibilities and requirements. If after reviewing, you are interested in learning more about this, or other opportunities within Life Sciences, please apply with your updated resume ASAP.

TITLE: Scientist I, Analytical and Formulation Development
LOCATION: South San Francisco, California
TYPE: Direct Hire/Permanent
INDUSTRY: Biotech
PAY: Competitive, depends on experience

PROFESSIONAL RESPONSIBILITIES:

* Develop HPLC (RP-HPLC), capillary electrophoresis and ELISA based analytical methods for protein/antibody characterization

* Serve as investigative lead on Probodies, PDCs and Bispecifics programs with respect to analytical methods (including but not limited to RP-HPLC, Ion exchange, Capillary electrophoresis, SE-HPLC and HIC)

* Apply scientific principles, current technologies, and personal experience to design and execute appropriate experiments to solve a given problem.

* Work closely with colleagues in Process Sciences to ensure timely analytical support for cell line, process, and formulation development.

* Partner with Protein Sciences to establish process and criteria for manufacturability assessments for clinical candidates at discovery stage

* Contribute to CMC sections in IND/CTA submissions and BLA/MAA submissions; evaluate comparability strategies and perform CQA assessments.

* Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities

* Maintain and troubleshoot analytical instrumentation as required

* Troubleshoot assay performance as needed

* Guide junior staff in development work

* Independently evaluate literature to propose strategic ideas for analytical method development for Probodies, PDCs and bispecifics

* Document experimental work in notebooks, SOPs and reports

* Communicate results and propose scientifically based recommendations

EDUCATION/EXPERIENCE:

* Ph.D. in Biochemistry, Analytical Chemistry or related discipline with 0 - 3+ years of experience in the biotechnology industry; Masters in Biochemistry, Analytical Chemistry or related discipline with 8+ years of experience in the biotechnology industry; Bachelors in Biochemistry, Analytical Chemistry or related discipline with 12+ years of experience in the biotechnology industry

PROFESSIONAL REQUIREMENTS:

* Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion); working knowledge of LC/MS is highly desirable.

* Strong analytical and critical thinking skills with the ability to interpret complex data.

* Ability to guide junior staff in method development work; previous supervisory experience preferred.

* Experience with performing developability or manufacturability assessments for therapeutic candidates is desirable.

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Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer, M/F/D/V. Click here:
http://www.yoh.com/applicants-with-disabilities
to contact us if you are an individual with a disability and require accommodation in the application process.

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