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Translational Medicine Lead at AstraZeneca

Posted in Other 30+ days ago.

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Location: Gaithersburg, Maryland





Job Description:
Position: Translational Medicine Lead, R&D Oncology

Location: Gaithersburg, MD USA

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

We are seeking a Translational Medicine Lead in Oncology R&D to join a world class center for discovery and development of innovative cancer medicines. In this role you will be accountable for delivery of robust, scientifically-driven biomarkers in drug discovery and development programs for immuno-oncology and ADC programs. You will have the opportunity to impact an industry-leading portfolio of immunotherapy and ADC programs from inception through to life cycle management for marketed drugs.

Key Responsibilities and Accountabilities:

  • In partnership with the Translational Medicine team, lead the implementation of strategic vision that enables target identification, indication selection, early indication of biological activity and patient stratification/selection in Oncology.
  • Deliver biomarkers for clinical studies based on the best available science and technologies.
  • Generate biomarker data to guide indication selection and identification of targeted patient populations.
  • Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
  • Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
  • Define novel mechanisms of resistance targeted therapies by studying tumors at relapse.
  • Collaborate with Oncology Research and product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early phases of development in Oncology.
  • Collaborate with clinical operations teams to implement exploratory sample collection and analyses in clinical studies related to oncology.
  • Manage internal and external research collaborations in areas of clinical technologies and oncology translational research.
  • Ensure complex clinical assays developed and validated internally or externally are fit for purpose.
  • Contribute to and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.


Essential Requirements and Qualifications

Education Required:
  • MD or PhD in a scientific discipline
  • Oncology training is required, preferably board certified or board eligible


Experience Required:
  • Extensive experience in drug development in pharmaceutical or biotech industries
  • In-depth knowledge of oncology disease area biology and translational science, ideally with expertise in immuno-oncology and/or antibody drug conjugates.
  • Proven communication, presentation and influencing skills.
  • Highly developed problem solving and risk management skills.
  • Ability to drive, manage, execute and deliver results for complex multi-functional projects.
  • Highly developed collaborative working skills.
  • Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.
  • Proven ability to motivate and develop others.


Next Steps - Apply Now!

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